Protein profile

KP13_00613

PilT domain-containing protein

Genome: KpKP13

Gene: AHE47087.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPK8
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Amino acids 127
Annotations 1
Features 9
PDB binders 0
Druggability 0.254

Overview

Basic information about this protein and its source genome.

Accession
KP13_00613
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47087.1
Status
annotated
Amino acids
127
Structure source
AlphaFold + ColabFold
GO
GO:0004540 Catalysis of the cleavage of phosphodiester bonds in chains of RNA.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.254
Structure A0A0H3GPK8
Pocket Pocket 7
P2Rank 0.183
Structure A0A0H3GPK8
Pocket Pocket 1
ColabFold model
FPocket 0.295 · Pocket 1
P2Rank 0.119 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 27 / 4744 genomes with a hit
Normalized 0.006

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004540 Catalysis of the cleavage of phosphodiester bonds in chains of RNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
7 122 CDD cd18737 PIN_VapC4-5_FitB-like
7 121 Gene3D G3DSA:3.40.50.1010 -
7 112 Pfam PF01850 PIN domain
7 112 InterPro IPR002716 PIN domain
6 119 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC].
6 119 InterPro IPR022907 VapC family
6 119 PANTHER PTHR33653 RIBONUCLEASE VAPC2
5 119 SUPERFAMILY SSF88723 PIN domain-like
5 119 InterPro IPR029060 PIN-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPK8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00613
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.254

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.51 0.07
2 1.41 0.018