Protein profile

KP13_00616

GCN5-related N-acetyltransferase

Genome: KpKP13

Gene: AHE47090.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GK19
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Amino acids 329
Annotations 5
Features 21
PDB binders 0
Druggability 0.22

Overview

Basic information about this protein and its source genome.

Accession
KP13_00616
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47090.1
Status
annotated
Amino acids
329
Structure source
AlphaFold + ColabFold
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006048 The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. GO:0004343 Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+. GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
91.185
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
87.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.22
Structure A0A0H3GK19
Pocket Pocket 11
P2Rank 0.816
Structure A0A0H3GK19
Pocket Pocket 1
ColabFold model
FPocket 0.202 · Pocket 14
P2Rank 0.818 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0006048 The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.
  • GO:0004343 Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H+.
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
  • GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
1 218 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
64 124 CDD cd04301 NAT_SF
18 162 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
18 162 InterPro IPR000182 GNAT domain
15 162 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
15 162 InterPro IPR016181 Acyl-CoA N-acyltransferase
18 140 PANTHER PTHR13355 GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE
18 140 InterPro IPR039143 Glucosamine 6-phosphate N-acetyltransferase
18 164 Gene3D G3DSA:3.40.630.30 -
174 313 Pfam PF09500 Putative thioesterase (yiiD_Cterm)
174 313 InterPro IPR012660 Thioesterase, putative
171 313 SUPERFAMILY SSF54637 Thioesterase/thiol ester dehydrase-isomerase
171 313 InterPro IPR029069 HotDog domain superfamily
165 315 Gene3D G3DSA:3.10.129.10 Hotdog Thioesterase
18 164 FunFam G3DSA:3.40.630.30:FF:000012 GNAT family acetyltransferase
44 138 Pfam PF00583 Acetyltransferase (GNAT) family
44 138 InterPro IPR000182 GNAT domain
241 329 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
181 314 NCBIfam TIGR02447 putative thioesterase domain
181 314 InterPro IPR012660 Thioesterase, putative
219 240 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GK19
AlphaFold — — full sequence — Viewing
ColabFold KP13_00616
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.22

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.5 0.724
2 6.4 0.322
3 1.98 0.042
4 1.93 0.039
5 1.87 0.037