Protein profile

KP13_00618

putative membrane protein

Genome: KpKP13

Gene: AHE47092.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GPK4
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Amino acids 286
Annotations 0
Features 32
PDB binders 0
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
KP13_00618
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47092.1
Status
annotated
Amino acids
286
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.561
DEG E-value
2.52e-81
Localization
CytoplasmicMembrane
ColabFold pLDDT
80.57

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure A0A0H3GPK4
Pocket Pocket 5
P2Rank 0.357
Structure A0A0H3GPK4
Pocket Pocket 1
ColabFold model
FPocket 0.92 · Pocket 30
P2Rank 0.512 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 96 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
1 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
240 266 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
141 163 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
17 281 Hamap MF_00672 UPF0761 membrane protein YihY [yihY].
17 281 InterPro IPR023679 Uncharacterised protein family UPF0761, bacterial
267 286 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
180 200 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
212 234 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
39 61 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
92 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
244 266 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
183 200 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
18 275 NCBIfam TIGR00765 YihY family inner membrane protein
18 275 InterPro IPR017039 Virulence factor BrkB
101 120 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
29 274 Pfam PF03631 Virulence factor BrkB
29 274 InterPro IPR017039 Virulence factor BrkB
201 211 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
39 61 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
73 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
103 120 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
161 179 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 286 PIRSF PIRSF035875 RNase_BN
1 286 InterPro IPR017039 Virulence factor BrkB
235 239 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
6 284 PANTHER PTHR30213 UNCHARACTERIZED
6 284 InterPro IPR017039 Virulence factor BrkB
62 72 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
141 160 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
212 234 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
121 140 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GPK4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00618
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.906
6 0.625
31 0.451

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.81 0.414
2 5.95 0.292
3 3.25 0.113
4 1.99 0.042
5 0.94 0.005