Protein profile

KP13_00631

putative acyltransferase

Genome: KpKP13

Gene: AHE47105.1 Structure source: ColabFold
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Amino acids 246
Annotations 1
Features 10
PDB binders 0
Druggability 0.973

Overview

Basic information about this protein and its source genome.

Accession
KP13_00631
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47105.1
Status
annotated
Amino acids
246
Structure source
ColabFold
GO
GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.426
DEG E-value
1.64e-60
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.49

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.973
Structure CB_KP13_00631
Pocket Pocket 22
P2Rank 0.762
Structure CB_KP13_00631
Pocket Pocket 1
ColabFold model
FPocket 0.973 · Pocket 22
P2Rank 0.762 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 82 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
22 158 Pfam PF01553 Acyltransferase
22 158 InterPro IPR002123 Phospholipid/glycerol acyltransferase
10 238 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
19 196 CDD cd07990 LPLAT_LCLAT1-like
88 246 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 68 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
30 242 PANTHER PTHR10983 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED
69 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
35 162 SMART SM00563 plsc_2
35 162 InterPro IPR002123 Phospholipid/glycerol acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold KP13_00631
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
22 0.973

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.64 0.657
2 6.89 0.354
3 3.69 0.14
4 2.22 0.054
5 1.73 0.031