Protein profile

KP13_00001

HTH transcriptional regulator

Genome: KpKP13

Gene: AHE47112.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GLA4
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Amino acids 233
Annotations 3
Features 24
PDB binders 1
Druggability 0.764

Overview

Basic information about this protein and its source genome.

Accession
KP13_00001
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47112.1
Status
annotated
Amino acids
233
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.8

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.764
Structure A0A0H3GLA4
Pocket Pocket 7
P2Rank 0.408
Structure A0A0H3GLA4
Pocket Pocket 1
ColabFold model
FPocket 0.699 · Pocket 4
P2Rank 0.297 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 102 / 4744 genomes with a hit
Normalized 0.022

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
102 231 Gene3D G3DSA:1.20.120.530 -
102 231 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
108 225 Pfam PF07729 FCD domain
108 225 InterPro IPR011711 GntR, C-terminal
37 51 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
37 51 InterPro IPR000524 Transcription regulator HTH, GntR
51 67 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
51 67 InterPro IPR000524 Transcription regulator HTH, GntR
11 81 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
11 81 InterPro IPR036390 Winged helix DNA-binding domain superfamily
18 77 CDD cd07377 WHTH_GntR
18 77 InterPro IPR000524 Transcription regulator HTH, GntR
2 79 Gene3D G3DSA:1.10.10.10 -
2 79 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
12 80 ProSiteProfiles PS50949 GntR-type HTH domain profile.
12 80 InterPro IPR000524 Transcription regulator HTH, GntR
2 79 FunFam G3DSA:1.10.10.10:FF:000251 Transcriptional regulator, GntR family
106 227 SMART SM00895 FCD_2
106 227 InterPro IPR011711 GntR, C-terminal
107 225 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
107 225 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
4 226 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
18 77 SMART SM00345 gntr3
18 77 Pfam PF00392 Bacterial regulatory proteins, gntR family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GLA4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00001
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.764

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.92 0.222
2 4.25 0.174

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3VV
4PDK
Q9KQU8 1032.0 Da LogP 4.70 TPSA 363.6 3 viol. ✓ Clean CCCCCCCC/C=C\CCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@@H…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.