Protein target profile

KP13_00011

ATPase ravA

Genome: KpKP13 Gene: AHE47122.1 ravA 3D evidence: AlphaFold DB model + ColabFold model UniProt A0A0H3GGS5
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Length 499
Pocket druggability 0.517
Functional annotation 0 EC 3 GO
Target summary

Target candidate with partial support; inspect missing evidence before prioritizing.

Automated synthesis of the evidence currently loaded. Review the underlying records before prioritizing this protein.

Main supporting evidence

No similar human protein detected The current BLAST sequence screen did not find a significant human match, lowering apparent off-target risk. Core gene across strains Marked as conserved by both pan-genome tools: Roary and CoreCruncher. Moderate predicted binding pocket FPocket selected-pocket score 0.52. This supports review but is not experimental validation. Structure available AlphaFold DB model + ColabFold model

Risks to review

Microbiome similarity 112 of 4744 screened genomes (2.4%) have a significant similarity hit. This target also has a predicted binding pocket (FPocket 0.52) — check the ligand evidence before deprioritizing on off-target risk alone. Weak second pocket-predictor signal P2Rank predicted binding-site probability 0.18.

Evidence gaps

No metabolic context No SBML/network-derived reaction evidence is loaded for this protein. No ligand evidence No experimental PDB ligands, measured ChEMBL bioactivity, or proposed ZINC compound records are available.
Terms and data sources used on this page

PDB: experimentally determined structures from the Protein Data Bank. These are the strongest structural evidence, but may cover only part of the protein.

AlphaFold DB model: a precomputed predicted structure downloaded from AlphaFold Database/UniProt, not an experiment performed here.

ColabFold model: a predicted structure generated for this workspace; interpret it with coverage and confidence.

pLDDT: confidence score for predicted structures. High values support local geometry; low values mean the region should not drive pocket interpretation.

FPocket / P2Rank: software tools that predict possible ligand-binding pockets on a 3D structure. They are useful screening signals, not experimental validation.

Druggability: a pocket-based estimate of whether a small molecule could bind productively. It does not mean a drug already exists.

PDB ligand: a compound observed in an experimental structure. Direct same-protein records are stronger than homolog-transferred records.

ChEMBL: a public database of measured compound bioactivity. Direct entries are stronger than entries transferred from similar proteins.

ZINC: a purchasable-compound database. Here it marks proposed candidates from chemical similarity, not measured binders.

LigQ / LigQ_2: an internal Target pipeline step that gathers PDB, ChEMBL, and ZINC ligand evidence for each protein.

Off-target: sequence similarity to proteins we prefer not to hit, such as human proteins or beneficial gut microbiome proteins.

DEG: Database of Essential Genes. A match suggests the protein resembles genes known to be essential in other organisms.

Roary / CoreCruncher: pan-genome tools used to decide whether a gene is core across analyzed strains or accessory/strain-specific.

EC / GO: functional annotations: EC describes enzyme reactions; GO describes biological process, molecular function, or cellular component.

KEGG pathway: a curated metabolic route label used here to group reactions imported from the metabolic model.

Chokepoint: a metabolic reaction that is the only producer or consumer of a metabolite in the imported model.

Prioritization evidence

Selectivity, essentiality, structural confidence, conservation, and predicted binding-site evidence.

Off-target risk

Human off-target
No hit
Gut microbiome similarity
2.4% of screened genomes Lower prevalence suggests narrower overlap with the screened gut microbiome.

Essentiality

Essential (DEG)
N
DEG identity (%)
0.0 Higher values support similarity to known essential genes.

Localization

Localization
Cytoplasmic

Structure confidence

ColabFold pLDDT
89.64 0-100 confidence; >70 supports local structural interpretation.

Binding-site evidence

AlphaFold DB / UniProt model

The selected pocket score is the FPocket value used for ranking after applying the curated structure priority. It estimates small-molecule pocket quality; it is not experimental binding evidence. The 3D viewer may show a different loaded structure, so visible pockets can differ.

FPocket 0.517
Structure A0A0H3GGS5
Pocket Pocket 11
P2Rank 0.18
Structure A0A0H3GGS5
Pocket Pocket 1
ColabFold model
FPocket 0.757 · Pocket 5
P2Rank 0.173 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Prevalence 2.4%

Cross-references

External database identifiers for this protein, its structures, ligands, and metabolic reactions.

Sequence

UniProt A0A0H3GGS5

Sequence

Primary amino-acid sequence viewer.

MAQTHLLAERISRLSAALEKGLFERSHAIRLCLLAALSGESVFLLGPPGIAKSLIARRLKFAFQQARAFEYLMTRFSTPEEVFGPLSIQALKDEGRYERLTAGYLPEAEIVFLDEIWKAGPAILNTLLTAINERHFRNGAHEEKIPMRLLVAASNELPEADSSLEALYDRMLIRLWLDKVQDKGNFRSMLVSQQDENSNPVPSALQVSDEEFTQWQQQIGNIKLPDAVFELIFQLRQQLDALPNAPYVSDRRWKKAIRLLQASAFFSGRDSIAPIDLILLKDCLWHNVESMNLMSQQLETLMTCHAWQQQAMLTRLGAIVQRRIQIQQQQSDKTALKVTRLGGMFSRKPHYELPAEIQGTTLTLLLQQPLKLHDMEVIHITFEREALANWLEKGGEIRGKLNGIGFAQLLNMDVDTSQHLVVRDVSLQGSRLALPGSAAQENMPAEIRQQLEALDDEWHQQHNRFSEQQKCLFIPVEWLGRIEASLQDVGAQIKQAKQP

Functional annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence domains and features

Domain and signature matches imported from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
1 221 Gene3D G3DSA:3.40.50.300 -
1 221 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 221 FunFam G3DSA:3.40.50.300:FF:000410 ATPase RavA
2 498 PANTHER PTHR32204 ATPASE RAVA
228 295 Pfam PF17868 AAA lid domain
228 295 InterPro IPR041538 ATPase RavA-like, AAA lid domain
23 175 CDD cd00009 AAA
288 493 Gene3D G3DSA:1.20.58.1510 -
11 213 Pfam PF20030 MoxR domain in the MoxR-vWA-beta-propeller ternary systems
11 213 InterPro IPR045427 MoxR domain
38 187 SMART SM00382 AAA_5
38 187 InterPro IPR003593 AAA+ ATPase domain
331 442 Gene3D G3DSA:2.40.128.430 -
331 442 InterPro IPR046932 ATPase RavA, LARA domain superfamily
444 498 Pfam PF12592 ATPase, RavA, C-terminal
444 498 InterPro IPR022547 ATPase, RavA, C-terminal
22 289 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
22 289 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
335 436 Pfam PF20265 ATPase, RavA, LARA domain
335 436 InterPro IPR046898 ATPase RavA, LARA domain

3D structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; AlphaFold DB and ColabFold models typically cover the full protein but remain computational predictions.

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Pocket score High Medium Low
How colors and pocket overlays are used
Uniform protein color marks the displayed model as a single molecular object.
Experimental PDB structures may be colored by chain to distinguish subunits or copies present in the file.
Pocket colors and alpha spheres are evidence overlays for predicted binding cavities; they are not alternative protein chains.
'Alpha spheres' is FPocket's own cavity-shape geometry, imported when available and aligned with the loaded structure.
'Pocket atoms'/'Predicted site atoms' show the pocket's residue atoms instead: P2Rank reports residues rather than alpha spheres, and FPocket falls back to this when alpha-sphere geometry is unavailable or doesn't align.
'No pocket geometry' means neither alpha spheres nor residue-position data could be found for that pocket; the layer just highlights the same residues as 'Nearby residues'.
Pocket details Inspect a specific pocket, or open the full viewer

Binding pockets · FPocket

Druggability: high ≥ 0.7 · medium 0.4–0.69 · low < 0.4

Site 1 FPocket #11
0.517
Likely same site as P2Rank 2 8.0 Å 2 shared residues 33% of smaller site
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Surrounding area
Site 2 FPocket #23
0.345
Likely same site as P2Rank 5 1.5 Å 7 shared residues 88% of smaller site
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Surrounding area
Site 3 FPocket #8
0.246
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Surrounding area

Binding pockets · P2Rank

Probability: high ≥ 0.5 · medium 0.2–0.49 · low < 0.2

Site 1 P2Rank #1
0.18
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Surrounding area
Site 2 P2Rank #2
0.065
Likely same site as FPocket 11 8.0 Å 2 shared residues 33% of smaller site
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Surrounding area
Site 3 P2Rank #3
0.042
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Surrounding area
Site 4 P2Rank #4
0.04
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Surrounding area
Site 5 P2Rank #5
0.025
Likely same site as FPocket 23 1.5 Å 7 shared residues 88% of smaller site
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Surrounding area
All structural evidence 0 experimental · 2 predicted

Structural evidence

0 + 2

Experimental PDB entries plus predicted AlphaFold DB or ColabFold models. Click Switch to display a different loaded structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold DB AF_A0A0H3GGS5
AlphaFold DB — — full sequence — Viewing
ColabFold KP13_00011
ColabFold — — full sequence — Loaded