Protein profile

KP13_00011

ATPase ravA

Genome: KpKP13

Gene: ravA AHE47122.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GGS5
Export view
Amino acids 499
Annotations 3
Features 20
PDB binders 0
Druggability 0.517

Overview

Basic information about this protein and its source genome.

Accession
KP13_00011
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
ravA AHE47122.1
Status
annotated
Amino acids
499
Structure source
AlphaFold + ColabFold
GO
GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.517
Structure A0A0H3GGS5
Pocket Pocket 11
P2Rank 0.18
Structure A0A0H3GGS5
Pocket Pocket 1
ColabFold model
FPocket 0.757 · Pocket 5
P2Rank 0.173 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 112 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
1 221 Gene3D G3DSA:3.40.50.300 -
1 221 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 221 FunFam G3DSA:3.40.50.300:FF:000410 ATPase RavA
2 498 PANTHER PTHR32204 ATPASE RAVA
228 295 Pfam PF17868 AAA lid domain
228 295 InterPro IPR041538 ATPase RavA-like, AAA lid domain
23 175 CDD cd00009 AAA
288 493 Gene3D G3DSA:1.20.58.1510 -
11 213 Pfam PF20030 MoxR domain in the MoxR-vWA-beta-propeller ternary systems
11 213 InterPro IPR045427 MoxR domain
38 187 SMART SM00382 AAA_5
38 187 InterPro IPR003593 AAA+ ATPase domain
331 442 Gene3D G3DSA:2.40.128.430 -
331 442 InterPro IPR046932 ATPase RavA, LARA domain superfamily
444 498 Pfam PF12592 ATPase, RavA, C-terminal
444 498 InterPro IPR022547 ATPase, RavA, C-terminal
22 289 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
22 289 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
335 436 Pfam PF20265 ATPase, RavA, LARA domain
335 436 InterPro IPR046898 ATPase RavA, LARA domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GGS5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00011
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.517
23 0.345
8 0.246

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.73 0.082
2 2.07 0.046
3 1.31 0.014
4 1.24 0.012
5 1.05 0.006