Protein profile

KP13_00012

Protein viaA

Genome: KpKP13

Gene: AHE47123.1 viaA Structure source: AlphaFold + ColabFold UniProt A0A0H3GL91
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Amino acids 482
Annotations 1
Features 12
PDB binders 0
Druggability 0.327

Overview

Basic information about this protein and its source genome.

Accession
KP13_00012
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47123.1 viaA
Status
annotated
Amino acids
482
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
85.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.327
Structure A0A0H3GL91
Pocket Pocket 16
P2Rank
Structure A0A0H3GL91
Pocket No pockets
ColabFold model
FPocket 0.274 · Pocket 9
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 108 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
317 454 SUPERFAMILY SSF53300 vWA-like
317 454 InterPro IPR036465 von Willebrand factor A-like domain superfamily
318 482 SMART SM00327 VWA_4
318 482 InterPro IPR002035 von Willebrand factor, type A
310 461 Gene3D G3DSA:3.40.50.410 von Willebrand factor, type A domain
310 461 InterPro IPR036465 von Willebrand factor A-like domain superfamily
28 480 PANTHER PTHR36846 PROTEIN VIAA
319 450 Pfam PF05762 VWA domain containing CoxE-like protein
319 450 InterPro IPR008912 Uncharacterised protein family CoxE-like
1 482 Hamap MF_01626 Protein ViaA [viaA].
1 482 InterPro IPR023481 Uncharacterised protein family ViaA
319 466 CDD cd01462 VWA_YIEM_type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GL91
AlphaFold — — full sequence — Viewing
ColabFold KP13_00012
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
16 0.327
31 0.269