Protein profile

KP13_00014

Regulatory protein asnC

Genome: KpKP13

Gene: AHE47125.1 asnC Structure source: AlphaFold + ColabFold UniProt A0A0H3GG41
Export view
Amino acids 152
Annotations 4
Features 26
PDB binders 1
Druggability 0.038

Overview

Basic information about this protein and its source genome.

Accession
KP13_00014
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47125.1 asnC
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043200 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
96.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.038
Structure A0A0H3GG41
Pocket Pocket 5
P2Rank 0.017
Structure A0A0H3GG41
Pocket Pocket 1
ColabFold model
FPocket 0.018 · Pocket 8
P2Rank 0.033 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 145 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043200 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
58 141 Gene3D G3DSA:3.30.70.920 -
1 57 Gene3D G3DSA:1.10.10.10 -
1 57 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
7 56 CDD cd00090 HTH_ARSR
7 56 InterPro IPR011991 ArsR-like helix-turn-helix domain
68 152 SUPERFAMILY SSF54909 Dimeric alpha+beta barrel
68 152 InterPro IPR011008 Dimeric alpha-beta barrel
58 141 FunFam G3DSA:3.30.70.920:FF:000002 Transcriptional regulator AsnC
4 66 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
4 66 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 57 FunFam G3DSA:1.10.10.10:FF:000078 Transcriptional regulator AsnC
6 67 ProSiteProfiles PS50956 AsnC-type HTH domain profile.
6 67 InterPro IPR000485 AsnC-type HTH domain
1 146 PANTHER PTHR43413 TRANSCRIPTIONAL REGULATOR, ASNC FAMILY
6 47 Pfam PF13404 AsnC-type helix-turn-helix domain
6 47 InterPro IPR000485 AsnC-type HTH domain
6 113 SMART SM00344 asnc
6 113 InterPro IPR019888 Transcription regulator AsnC-like
22 33 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature
22 33 InterPro IPR000485 AsnC-type HTH domain
33 52 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature
33 52 InterPro IPR000485 AsnC-type HTH domain
6 22 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature
6 22 InterPro IPR000485 AsnC-type HTH domain
76 143 Pfam PF01037 Lrp/AsnC ligand binding domain
76 143 InterPro IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GG41 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GG41
AlphaFold — — full sequence — Viewing
ColabFold KP13_00014
ColabFold — — full sequence — Loaded

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
MSE
2E1A
O73983 196.1 Da LogP -0.04 TPSA 63.3 ✓ Ro5 ✓ Clean C[Se]CC[C@@H](C(=O)O)N

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.