Protein profile

KP13_07162

Ribosomal RNA small subunit methyltransferase G

Genome: KpKP13

Gene: rsmG ANJ86652.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXV3
Export view
Amino acids 207
Annotations 6
Features 16
PDB binders 1
Druggability 0.487

Overview

Basic information about this protein and its source genome.

Accession
KP13_07162
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rsmG ANJ86652.1
Status
annotated
Amino acids
207
Structure source
AlphaFold + ColabFold
EC
2.1.1.170
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008649 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0070043 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.93

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.487
Structure A0A0H3GXV3
Pocket Pocket 1
P2Rank 0.144
Structure A0A0H3GXV3
Pocket Pocket 1
ColabFold model
FPocket 0.279 · Pocket 6
P2Rank 0.118 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 143 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008649 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside.
  • GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0070043 Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 207 PIRSF PIRSF003078 GidB
1 207 InterPro IPR003682 rRNA small subunit methyltransferase G
68 162 CDD cd02440 AdoMet_MTases
1 206 FunFam G3DSA:3.40.50.150:FF:000032 Ribosomal RNA small subunit methyltransferase G
1 206 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
1 206 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
3 205 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
3 205 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
20 200 Pfam PF02527 rRNA small subunit methyltransferase G
20 200 InterPro IPR003682 rRNA small subunit methyltransferase G
14 205 PANTHER PTHR31760 S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN
14 205 InterPro IPR003682 rRNA small subunit methyltransferase G
25 203 NCBIfam TIGR00138 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG
25 203 InterPro IPR003682 rRNA small subunit methyltransferase G
13 201 Hamap MF_00074 Ribosomal RNA small subunit methyltransferase G [rsmG].
13 201 InterPro IPR003682 rRNA small subunit methyltransferase G

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXV3
AlphaFold — — full sequence — Viewing
ColabFold KP13_07162
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.487
4 0.072
3 0.027
7 0.006

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.25 0.144
2 1.45 0.016

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
SFG
7CFE
P9WGW9 381.4 Da LogP -2.06 TPSA 208.7 2 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.