Protein profile

KP13_00021

ATP synthase subunit b

Genome: KpKP13

Gene: AHE47130.1 atpF Structure source: AlphaFold + ColabFold UniProt A0A0H3H4Y3
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Amino acids 154
Annotations 8
Features 17
PDB binders 0
Druggability 0.552

Overview

Basic information about this protein and its source genome.

Accession
KP13_00021
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47130.1 atpF
Status
annotated
Amino acids
154
Structure source
AlphaFold + ColabFold
GO
GO:0015078 Enables the transfer of a proton from one side of a membrane to the other. GO:0015986 The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0045263 OBSOLETE. All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259 A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.805
DEG E-value
1.0600000000000001e-99
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.13

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.552
Structure A0A0H3H4Y3
Pocket Pocket 10
P2Rank
Structure A0A0H3H4Y3
Pocket No pockets
ColabFold model
FPocket 0.506 · Pocket 6
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 148 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8
  • GO:0015078 Enables the transfer of a proton from one side of a membrane to the other.
  • GO:0015986 The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force).
  • GO:0045263 OBSOLETE. All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins.
  • GO:0012505 A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0045259 A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
  • GO:0046933 Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in).
  • GO:0046961 Enables the transfer of protons from one side of a membrane to the other by a rotational mechanism according to the reaction: ATP + H2O + 4 H+(in) => ADP + phosphate + 5 H+(out).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 120 FunFam G3DSA:1.20.5.620:FF:000001 ATP synthase subunit b
42 120 Coils Coil Coil
6 24 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
4 135 Pfam PF00430 ATP synthase B/B' CF(0)
4 135 InterPro IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast
1 136 Hamap MF_01398 ATP synthase subunit b [atpF].
1 136 InterPro IPR002146 ATP synthase, F0 complex, subunit b/b', bacterial/chloroplast
60 120 Gene3D G3DSA:1.20.5.620 F1F0 ATP synthase subunit B, membrane domain
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
8 154 NCBIfam TIGR01144 F0F1 ATP synthase subunit B
8 154 InterPro IPR005864 ATP synthase, F0 complex, subunit b, bacterial
2 154 PANTHER PTHR33445 ATP SYNTHASE SUBUNIT B', CHLOROPLASTIC
25 154 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
61 119 SUPERFAMILY SSF81573 F1F0 ATP synthase subunit B, membrane domain
61 119 InterPro IPR028987 F-type ATP synthase subunit B-like, membrane domain superfamily
4 135 CDD cd06503 ATP-synt_Fo_b

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4Y3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00021
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.552
4 0.278
9 0.235