Protein profile

KP13_00026

ATP synthase epsilon chain

Genome: KpKP13

Gene: atpC AHE47135.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4X9
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Amino acids 139
Annotations 6
Features 21
PDB binders 1
Druggability 0.499

Overview

Basic information about this protein and its source genome.

Accession
KP13_00026
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
atpC AHE47135.1
Status
annotated
Amino acids
139
Structure source
AlphaFold + ColabFold
GO
GO:0045261 OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. GO:0015986 The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force). GO:0046933 Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259 A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
97.122
DEG E-value
8.4e-97
Localization
Cytoplasmic
ColabFold pLDDT
82.06

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.499
Structure A0A0H3H4X9
Pocket Pocket 4
P2Rank 0.005
Structure A0A0H3H4X9
Pocket Pocket 1
ColabFold model
FPocket 0.23 · Pocket 3
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 194 / 4744 genomes with a hit
Normalized 0.041

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6
  • GO:0045261 OBSOLETE. The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.
  • GO:0015986 The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force).
  • GO:0046933 Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in).
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0045259 A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records
Show feature table
Start End DB Term Name
5 132 PANTHER PTHR13822 ATP SYNTHASE DELTA/EPSILON CHAIN
5 132 InterPro IPR001469 ATP synthase, F1 complex, delta/epsilon subunit
91 134 Gene3D G3DSA:1.20.5.440 -
91 134 FunFam G3DSA:1.20.5.440:FF:000001 ATP synthase epsilon chain
6 127 CDD cd12152 F1-ATPase_delta
6 127 InterPro IPR001469 ATP synthase, F1 complex, delta/epsilon subunit
3 90 Gene3D G3DSA:2.60.15.10 -
3 90 InterPro IPR036771 F0F1 ATP synthase delta/epsilon subunit, N-terminal
3 131 Hamap MF_00530 ATP synthase epsilon chain [atpC].
3 131 InterPro IPR001469 ATP synthase, F1 complex, delta/epsilon subunit
88 137 SUPERFAMILY SSF46604 Epsilon subunit of F1F0-ATP synthase C-terminal domain
88 137 InterPro IPR036794 ATP synthase delta/epsilon subunit, C-terminal domain superfamily
6 84 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain
6 84 InterPro IPR020546 ATP synthase, F1 complex, delta/epsilon subunit, N-terminal
3 90 FunFam G3DSA:2.60.15.10:FF:000001 ATP synthase epsilon chain
89 133 Pfam PF00401 ATP synthase, Delta/Epsilon chain, long alpha-helix domain
89 133 InterPro IPR020547 ATP synthase epsilon subunit, C-terminal domain
3 86 SUPERFAMILY SSF51344 Epsilon subunit of F1F0-ATP synthase N-terminal domain
3 86 InterPro IPR036771 F0F1 ATP synthase delta/epsilon subunit, N-terminal
4 133 NCBIfam TIGR01216 ATP synthase F1 subunit epsilon
4 133 InterPro IPR001469 ATP synthase, F1 complex, delta/epsilon subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4X9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00026
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.499

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
CAC
6PI4
A0R1Z9 137.0 Da LogP -0.52 TPSA 40.1 ✓ Ro5 ✓ Clean C[As](=O)(C)[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.