Protein profile

KP13_00030

Phosphate-binding protein pstS

Genome: KpKP13

Gene: pstS AHE47139.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXT2
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Amino acids 329
Annotations 3
Features 18
PDB binders 1
Druggability 0.693

Overview

Basic information about this protein and its source genome.

Accession
KP13_00030
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pstS AHE47139.1
Status
annotated
Amino acids
329
Structure source
AlphaFold + ColabFold
GO
GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0035435 The process in which a phosphate is transported across a membrane. GO:0042301 Binding to a phosphate ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
89.937
DEG E-value
0.0
Localization
Periplasmic
ColabFold pLDDT
96.87

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.693
Structure A0A0H3GXT2
Pocket Pocket 5
P2Rank 0.124
Structure A0A0H3GXT2
Pocket Pocket 1
ColabFold model
FPocket 0.907 · Pocket 3
P2Rank 0.089 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 156 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043190 A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
  • GO:0035435 The process in which a phosphate is transported across a membrane.
  • GO:0042301 Binding to a phosphate ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
2 321 PIRSF PIRSF002756 PstS
2 321 InterPro IPR005673 Phosphate ABC transporter, substrate-binding protein PstS
12 300 CDD cd13565 PBP2_PstS
6 318 PANTHER PTHR42996 PHOSPHATE-BINDING PROTEIN PSTS
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
26 329 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
11 321 SUPERFAMILY SSF53850 Periplasmic binding protein-like II
8 290 Pfam PF12849 PBP superfamily domain
8 290 InterPro IPR024370 PBP domain
14 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
86 261 Gene3D G3DSA:3.40.190.10 -
1 17 SignalP_EUK SignalP-noTM SignalP-noTM
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
12 309 Gene3D G3DSA:3.40.190.10 -
12 318 NCBIfam TIGR00975 phosphate ABC transporter substrate-binding protein PstS
12 318 InterPro IPR005673 Phosphate ABC transporter, substrate-binding protein PstS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXT2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00030
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.693

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.39 0.064

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
8AR
4F18
C3K8K1 139.9 Da LogP -3.43 TPSA 83.4 ✓ Ro5 ✓ Clean O[As](=O)([O-])[O-]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.