Protein profile

KP13_00031

Phosphate transport system permease protein pstC

Genome: KpKP13

Gene: pstC AHE47140.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ28
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Amino acids 319
Annotations 5
Features 32
PDB binders 0
Druggability 0.726

Overview

Basic information about this protein and its source genome.

Accession
KP13_00031
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
pstC AHE47140.1
Status
annotated
Amino acids
319
Structure source
AlphaFold + ColabFold
GO
GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006817 The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
94.671
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.726
Structure A0A0H3GZ28
Pocket Pocket 5
P2Rank 0.031
Structure A0A0H3GZ28
Pocket Pocket 1
ColabFold model
FPocket 0.984 · Pocket 2
P2Rank 0.014 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 156 / 4744 genomes with a hit
Normalized 0.033

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0006817 The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

32 records
Show feature table
Start End DB Term Name
101 111 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
75 272 CDD cd06261 TM_PBP2
75 272 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
282 304 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
95 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
95 304 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
156 186 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
282 304 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
75 100 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
44 74 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
17 311 NCBIfam TIGR02138 phosphate ABC transporter permease subunit PstC
17 311 InterPro IPR011864 Phosphate ABC transporter, permease protein PstC
21 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
18 311 Gene3D G3DSA:1.10.3720.10 -
18 311 InterPro IPR035906 MetI-like superfamily
16 316 PANTHER PTHR30425 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PST
166 188 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
242 262 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
305 319 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
263 281 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
78 100 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 20 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
187 241 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
137 155 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
75 305 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
75 305 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
227 249 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 136 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 303 SUPERFAMILY SSF161098 MetI-like
28 303 InterPro IPR035906 MetI-like superfamily
112 134 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ28
AlphaFold — — full sequence — Viewing
ColabFold KP13_00031
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.726
8 0.679
9 0.426
3 0.278

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.46 0.067
2 1.51 0.022
3 1.47 0.02