Protein profile

KP13_00032

Phosphate transport system permease protein pstA

Genome: KpKP13

Gene: AHE47141.1 pstA Structure source: AlphaFold + ColabFold UniProt A0A0H3H0I8
Export view
Amino acids 296
Annotations 5
Features 33
PDB binders 0
Druggability 0.598

Overview

Basic information about this protein and its source genome.

Accession
KP13_00032
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47141.1 pstA
Status
annotated
Amino acids
296
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0035435 The process in which a phosphate is transported across a membrane. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
45.421
DEG E-value
9.58e-79
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.89

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.598
Structure A0A0H3H0I8
Pocket Pocket 20
P2Rank 0.248
Structure A0A0H3H0I8
Pocket Pocket 1
ColabFold model
FPocket 0.601 · Pocket 14
P2Rank 0.304 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 152 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0005315 Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0035435 The process in which a phosphate is transported across a membrane.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

33 records
Show feature table
Start End DB Term Name
170 200 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
29 51 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
150 169 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
112 122 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 28 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
27 293 Gene3D G3DSA:1.10.3720.10 -
27 293 InterPro IPR035906 MetI-like superfamily
101 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
101 289 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
51 88 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
123 145 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
146 150 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
28 293 FunFam G3DSA:1.10.3720.10:FF:000026 Phosphate transport system permease protein PstA
29 50 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
268 290 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
151 169 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
14 294 PANTHER PTHR42922 PHOSPHATE TRANSPORT SYSTEM PERMEASE PROTEIN PSTA
267 290 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 238 CDD cd06261 TM_PBP2
83 238 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
223 266 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83 286 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
83 286 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
35 286 SUPERFAMILY SSF161098 MetI-like
35 286 InterPro IPR035906 MetI-like superfamily
291 296 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
201 222 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
28 294 NCBIfam TIGR00974 phosphate ABC transporter permease PstA
28 294 InterPro IPR005672 Phosphate transport system permease protein PstA
123 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
89 111 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
88 110 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0I8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00032
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.598
1 0.417

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.33 0.118
2 2.02 0.044
3 1.64 0.027