Protein profile

KP13_00036

putative hydrolase

Genome: KpKP13

Gene: AHE47147.1 Structure source: AlphaFold + ColabFold UniProt A0A0C7KF67
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Amino acids 388
Annotations 4
Features 22
PDB binders 1
Druggability 0.386

Overview

Basic information about this protein and its source genome.

Accession
KP13_00036
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47147.1
Status
annotated
Amino acids
388
Structure source
AlphaFold + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0045493 The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
70.876
DEG E-value
0.0
Localization
Unknown
ColabFold pLDDT
95.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.386
Structure A0A0C7KF67
Pocket Pocket 7
P2Rank 0.725
Structure A0A0C7KF67
Pocket Pocket 1
ColabFold model
FPocket 0.596 · Pocket 15
P2Rank 0.808 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 31 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond.
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0045493 The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
45 128 CDD cd11294 E_set_Esterase_like_N
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 21 SignalP_EUK SignalP-noTM SignalP-noTM
130 388 Gene3D G3DSA:3.40.50.1820 alpha/beta hydrolase
130 388 InterPro IPR029058 Alpha/Beta hydrolase fold
135 388 SUPERFAMILY SSF53474 alpha/beta-Hydrolases
135 388 InterPro IPR029058 Alpha/Beta hydrolase fold
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
110 387 PANTHER PTHR48098 ENTEROCHELIN ESTERASE-RELATED
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
22 388 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
32 125 Gene3D G3DSA:2.60.40.10 Immunoglobulins
32 125 InterPro IPR013783 Immunoglobulin-like fold
42 102 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
42 102 InterPro IPR004193 Glycoside hydrolase, family 13, N-terminal
149 378 Pfam PF00756 Putative esterase
149 378 InterPro IPR000801 Esterase-like
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
43 103 SUPERFAMILY SSF81296 E set domains
43 103 InterPro IPR014756 Immunoglobulin E-set

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0C7KF67
AlphaFold — — full sequence — Viewing
ColabFold KP13_00036
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.386
5 0.262

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 11.71 0.622
2 3.26 0.113
3 2.13 0.05
4 0.95 0.005

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
FER
5CXX
F2YCB6 194.2 Da LogP 1.50 TPSA 66.8 ✓ Ro5 ✓ Clean COc1cc(ccc1O)\C=C\C(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.