Protein profile

KP13_00038

Phosphatase

Genome: KpKP13

Gene: AHE47149.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXS5
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Amino acids 221
Annotations 2
Features 20
PDB binders 4
Druggability 0.924

Overview

Basic information about this protein and its source genome.

Accession
KP13_00038
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47149.1
Status
annotated
Amino acids
221
Structure source
AlphaFold + ColabFold
GO
GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.55

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924
Structure A0A0H3GXS5
Pocket Pocket 2
P2Rank 0.879
Structure A0A0H3GXS5
Pocket Pocket 1
ColabFold model
FPocket 0.571 · Pocket 3
P2Rank 0.886 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 94 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
61 183 NCBIfam TIGR01509 HAD-IA family hydrolase
61 183 InterPro IPR006439 HAD hydrolase, subfamily IA
19 86 Gene3D G3DSA:1.10.150.240 Putative phosphatase; domain 2
19 86 InterPro IPR023198 Phosphoglycolate phosphatase-like, domain 2
5 187 CDD cd07526 HAD_BPGM_like
5 212 SFLD SFLDG01129 C1.5: HAD, Beta-PGM, Phosphatase Like
5 212 SFLD SFLDS00003 Haloacid Dehalogenase
1 204 PANTHER PTHR46193 6-PHOSPHOGLUCONATE PHOSPHATASE
4 212 SUPERFAMILY SSF56784 HAD-like
4 212 InterPro IPR036412 HAD-like superfamily
7 193 Gene3D G3DSA:3.40.50.1000 -
7 193 InterPro IPR023214 HAD superfamily
7 183 Pfam PF13419 Haloacid dehalogenase-like hydrolase
7 183 InterPro IPR041492 Haloacid dehalogenase-like hydrolase
4 15 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature
4 15 InterPro IPR006439 HAD hydrolase, subfamily IA
97 110 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature
97 110 InterPro IPR006439 HAD hydrolase, subfamily IA
129 145 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature
129 145 InterPro IPR006439 HAD hydrolase, subfamily IA

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXS5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00038
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.924

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.53 0.804
2 2.69 0.08
3 1.59 0.025

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

21 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2OP
2W11
Q96XE7 90.1 Da LogP -0.55 TPSA 57.5 ✓ Ro5 ✓ Clean C[C@@H](C(=O)O)O
MLT
3QUT
Q8A5V9 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
PGA
1TE2
P77247 156.0 Da LogP -0.82 TPSA 104.1 ✓ Ro5 ✓ Clean C(C(=O)O)OP(=O)(O)O
TLA
3QU9
Q8A5V9 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.