Protein profile

KP13_00046

Inner membrane protein oxaA

Genome: KpKP13

Gene: oxaA AHE47157.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4V7
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Amino acids 548
Annotations 5
Features 63
PDB binders 0
Druggability 0.913

Overview

Basic information about this protein and its source genome.

Accession
KP13_00046
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
oxaA AHE47157.1
Status
annotated
Amino acids
548
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
27.536
Human E-value
2.25e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
87.978
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
86.7

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.913
Structure A0A0H3H4V7
Pocket Pocket 11
P2Rank 0.937
Structure A0A0H3H4V7
Pocket Pocket 1
ColabFold model
FPocket 0.821 · Pocket 35
P2Rank 0.86 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 147 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0032977 Binds transmembrane domain-containing proteins and mediates their integration into a membrane.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

63 records
Show feature table
Start End DB Term Name
374 416 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
60 343 Pfam PF14849 YidC periplasmic domain
60 343 InterPro IPR028053 Membrane insertase YidC, N-terminal
494 519 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
28 50 MobiDBLite mobidb-lite consensus disorder prediction
354 533 Pfam PF02096 60Kd inner membrane protein
354 533 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
441 463 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
7 24 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
324 344 PRINTS PR00701 60kDa inner membrane protein signature
324 344 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
415 438 PRINTS PR00701 60kDa inner membrane protein signature
415 438 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
157 177 PRINTS PR00701 60kDa inner membrane protein signature
157 177 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
65 86 PRINTS PR00701 60kDa inner membrane protein signature
65 86 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
2 23 PRINTS PR00701 60kDa inner membrane protein signature
2 23 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
217 235 PRINTS PR00701 60kDa inner membrane protein signature
217 235 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
462 484 PRINTS PR00701 60kDa inner membrane protein signature
462 484 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
499 522 PRINTS PR00701 60kDa inner membrane protein signature
499 522 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
251 266 PRINTS PR00701 60kDa inner membrane protein signature
251 266 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
4 535 Hamap MF_01810 Membrane protein insertase YidC [yidC].
4 535 InterPro IPR019998 Membrane insertase YidC
354 373 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
3 352 NCBIfam TIGR03593 membrane protein insertase, YidC/Oxa1 family, N-terminal domain
3 352 InterPro IPR028053 Membrane insertase YidC, N-terminal
520 548 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
483 493 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
55 335 FunFam G3DSA:2.70.98.90:FF:000001 Membrane protein insertase YidC
464 482 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
355 533 CDD cd20070 5TM_YidC_Alb3
355 533 InterPro IPR047196 Membrane insertase YidC/ALB, C-terminal
339 355 PRINTS PR01900 YidC translocation/secretion protein signature
339 355 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
468 483 PRINTS PR01900 YidC translocation/secretion protein signature
468 483 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
488 512 PRINTS PR01900 YidC translocation/secretion protein signature
488 512 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
28 47 MobiDBLite mobidb-lite consensus disorder prediction
313 538 PANTHER PTHR12428 OXA1
313 538 InterPro IPR001708 Membrane insertase YidC/ALB3/OXA1/COX18
55 335 Gene3D G3DSA:2.70.98.90 -
55 335 InterPro IPR038221 YidC, periplasmic domain superfamily
58 330 CDD cd19961 EcYidC-like_peri
58 330 InterPro IPR028053 Membrane insertase YidC, N-terminal
417 439 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 353 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
497 519 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
350 372 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
353 533 NCBIfam TIGR03592 membrane protein insertase YidC
353 533 InterPro IPR028055 Membrane insertase YidC/Oxa/ALB, C-terminal
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
417 440 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4V7
AlphaFold — — full sequence — Viewing
ColabFold KP13_00046
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.913

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 26.47 0.914
2 5.47 0.261
3 3.13 0.106
4 2.21 0.053
5 2.12 0.049