Protein profile

KP13_05720

Resolvase

Genome: KpKP13

Gene: AHE41810.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8C5
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Amino acids 328
Annotations 3
Features 16
PDB binders 0
Druggability 0.394

Overview

Basic information about this protein and its source genome.

Accession
KP13_05720
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41810.1
Status
annotated
Amino acids
328
Structure source
AlphaFold + ColabFold
GO
GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.394
Structure A0A1C8Y8C5
Pocket Pocket 28
P2Rank 0.417
Structure A0A1C8Y8C5
Pocket Pocket 1
ColabFold model
FPocket 0.333 · Pocket 7
P2Rank 0.076 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
18 174 PANTHER PTHR30461 DNA-INVERTASE FROM LAMBDOID PROPHAGE
16 169 SUPERFAMILY SSF53041 Resolvase-like
16 169 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
16 159 CDD cd03767 SR_Res_par
19 27 ProSitePatterns PS00397 Site-specific recombinases active site.
19 27 InterPro IPR006118 Recombinase, conserved site
16 169 SMART SM00857 resolvase_6
16 169 InterPro IPR006119 Resolvase, N-terminal catalytic domain
15 178 FunFam G3DSA:3.40.50.1390:FF:000010 Recombinase resolvase family
15 179 Gene3D G3DSA:3.40.50.1390 -
15 179 InterPro IPR036162 Resolvase-like, N-terminal catalytic domain superfamily
15 167 ProSiteProfiles PS51736 Resolvase/invertase-type recombinase catalytic domain profile.
15 167 InterPro IPR006119 Resolvase, N-terminal catalytic domain
18 169 Pfam PF00239 Resolvase, N terminal domain
18 169 InterPro IPR006119 Resolvase, N-terminal catalytic domain
146 166 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8C5
AlphaFold — — full sequence — Viewing
ColabFold KP13_05720
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.394

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.8 0.283
2 1.4 0.017