Protein profile

KP13_32103

initiator RepB protein

Genome: KpKP13

Gene: AHE41818.1 repB Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8C7
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Amino acids 337
Annotations 2
Features 14
PDB binders 0
Druggability 0.146

Overview

Basic information about this protein and its source genome.

Accession
KP13_32103
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41818.1 repB
Status
annotated
Amino acids
337
Structure source
AlphaFold + ColabFold
GO
GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. GO:0006270 The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
75.31

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.146
Structure A0A1C8Y8C7
Pocket Pocket 25
P2Rank 0.039
Structure A0A1C8Y8C7
Pocket Pocket 1
ColabFold model
FPocket 0.31 · Pocket 22
P2Rank 0.078 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time.
  • GO:0006270 The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
197 310 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
197 310 InterPro IPR036390 Winged helix DNA-binding domain superfamily
61 307 Pfam PF01051 Initiator Replication protein
61 307 InterPro IPR000525 Initiator Rep protein
59 195 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
59 195 InterPro IPR036390 Winged helix DNA-binding domain superfamily
1 21 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
212 320 Gene3D G3DSA:1.10.10.10 -
212 320 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
49 211 Gene3D G3DSA:1.10.10.10 -
49 211 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
43 337 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
22 42 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8C7
AlphaFold — — full sequence — Viewing
ColabFold KP13_32103
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.78 0.033