Protein profile

KP13_05741

bacterial antitermination protein NusG

Genome: KpKP13

Gene: AHE41831.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8D7
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Amino acids 169
Annotations 3
Features 9
PDB binders 0
Druggability 0.91

Overview

Basic information about this protein and its source genome.

Accession
KP13_05741
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41831.1
Status
annotated
Amino acids
169
Structure source
AlphaFold + ColabFold
GO
GO:0140673 A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
85.16

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.91
Structure A0A1C8Y8D7
Pocket Pocket 1
P2Rank 0.008
Structure A0A1C8Y8D7
Pocket Pocket 1
ColabFold model
FPocket 0.28 · Pocket 11
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0140673 A chromatin remodeling process that reestablishes the chromatin structure following the passage of RNA polymerase II during transcription elongation, thus preventing cryptic transcription initiation.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0006354 The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 98 Pfam PF02357 Transcription termination factor nusG
1 98 InterPro IPR006645 NusG-like, N-terminal
1 101 SUPERFAMILY SSF82679 N-utilization substance G protein NusG, N-terminal domain
1 101 InterPro IPR036735 NusG, N-terminal domain superfamily
1 100 CDD cd09894 NGN_SP_AnfA1
1 153 Gene3D G3DSA:3.30.70.940 -
1 153 InterPro IPR036735 NusG, N-terminal domain superfamily
1 102 SMART SM00738 nusgn_4
1 102 InterPro IPR006645 NusG-like, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8D7
AlphaFold — — full sequence — Viewing
ColabFold KP13_05741
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.91