Protein profile

KP13_06886

conjugal transfer TrbC-like protein

Genome: KpKP13

Gene: AHE41833.1 Structure source: AlphaFold + ColabFold UniProt A0A411KVU2
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Amino acids 102
Annotations 0
Features 15
PDB binders 0
Druggability 0.717

Overview

Basic information about this protein and its source genome.

Accession
KP13_06886
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41833.1
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
53.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.717
Structure A0A411KVU2
Pocket Pocket 13
P2Rank 0.016
Structure A0A411KVU2
Pocket Pocket 1
ColabFold model
FPocket 0.964 · Pocket 8
P2Rank 0.299 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
80 97 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
55 73 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
13 35 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 34 SignalP_GRAM_NEGATIVE SignalP-TM SignalP-TM
35 57 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
15 26 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
74 79 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 100 Pfam PF04956 TrbC/VIRB2 pilin
7 100 InterPro IPR007039 Conjugal transfer TrbC/type IV secretion VirB2
27 34 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
98 102 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 14 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 34 Phobius SIGNAL_PEPTIDE Signal peptide region
58 73 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
80 97 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A411KVU2
AlphaFold — — full sequence — Viewing
ColabFold KP13_06886
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
13 0.717
12 0.554