Protein profile

KP13_06730

conjugal transfer TrbE-like protein

Genome: KpKP13

Gene: trbE AHE41834.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8F2
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Amino acids 891
Annotations 2
Features 13
PDB binders 0
Druggability 0.737

Overview

Basic information about this protein and its source genome.

Accession
KP13_06730
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
trbE AHE41834.1
Status
annotated
Amino acids
891
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
91.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.737
Structure A0A1C8Y8F2
Pocket Pocket 11
P2Rank 0.368
Structure A0A1C8Y8F2
Pocket Pocket 1
ColabFold model
FPocket 0.535 · Pocket 3
P2Rank 0.281 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
246 448 Pfam PF03135 CagE, TrbE, VirB family, component of type IV transporter system
246 448 InterPro IPR018145 CagE, TrbE, VirB component of type IV transporter system, central domain
511 800 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
511 800 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
658 835 Gene3D G3DSA:3.40.50.300 -
658 835 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 1 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
19 891 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
451 831 PANTHER PTHR30121 UNCHARACTERIZED PROTEIN YJGR-RELATED
2 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8F2
AlphaFold — — full sequence — Viewing
ColabFold KP13_06730
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
11 0.737
56 0.389
23 0.359

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.61 0.269
2 4.55 0.196
3 4.4 0.185
4 3.69 0.14
5 2.5 0.069