Protein profile

KP13_06731

type IV conjugative transfer system virB5-like protein

Genome: KpKP13

Gene: AHE41835.1 virB5 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8F0
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Amino acids 256
Annotations 0
Features 15
PDB binders 0
Druggability 0.852

Overview

Basic information about this protein and its source genome.

Accession
KP13_06731
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41835.1 virB5
Status
annotated
Amino acids
256
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
74.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.852
Structure A0A1C8Y8F0
Pocket Pocket 1
P2Rank 0.507
Structure A0A1C8Y8F0
Pocket Pocket 1
ColabFold model
FPocket 0.802 · Pocket 2
P2Rank 0.229 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 1 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
22 221 SUPERFAMILY SSF101082 Typo IV secretion system protein TraC
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
22 256 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
38 214 Pfam PF07996 Type IV secretion system proteins
38 214 InterPro IPR014158 Type IV secretion system, VirB5
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
154 181 Coils Coil Coil
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
37 64 Coils Coil Coil
34 225 Gene3D G3DSA:1.20.58.430 -
34 225 InterPro IPR023220 Type IV secretion system, VirB5-domain
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8F0
AlphaFold — — full sequence — Viewing
ColabFold KP13_06731
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.852
2 0.375

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.8 0.348
2 1.27 0.013