Protein profile

KP13_06733

conjugal transfer TrbL-like protein

Genome: KpKP13

Gene: trbL AHE41837.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8E9
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Amino acids 351
Annotations 2
Features 18
PDB binders 0
Druggability 0.998

Overview

Basic information about this protein and its source genome.

Accession
KP13_06733
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
trbL AHE41837.1
Status
annotated
Amino acids
351
Structure source
AlphaFold + ColabFold
GO
GO:0030255 The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
74.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.998
Structure A0A1C8Y8E9
Pocket Pocket 2
P2Rank 0.633
Structure A0A1C8Y8E9
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 2
P2Rank 0.562 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030255 The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
166 183 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
212 230 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
251 351 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
42 252 Pfam PF04610 TrbL/VirB6 plasmid conjugal transfer protein
42 252 InterPro IPR007688 Plasmid conjugal transfer TrbL/VirB6
137 159 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
161 165 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
66 85 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
193 215 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
184 189 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 134 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
166 183 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
228 250 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
135 160 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
260 282 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
190 211 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
231 250 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 54 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8E9
AlphaFold — — full sequence — Viewing
ColabFold KP13_06733
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.998
29 0.723
6 0.613
16 0.513

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.67 0.73
2 5.34 0.253
3 2.11 0.048
4 1.95 0.04
5 1.64 0.027