Protein profile

KP13_06739

conjugal transfer TraG-like protein

Genome: KpKP13

Gene: traG AHE41843.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8F4
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Amino acids 611
Annotations 2
Features 17
PDB binders 0
Druggability 0.692

Overview

Basic information about this protein and its source genome.

Accession
KP13_06739
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
traG AHE41843.1
Status
annotated
Amino acids
611
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.692
Structure A0A1C8Y8F4
Pocket Pocket 5
P2Rank 0.519
Structure A0A1C8Y8F4
Pocket Pocket 1
ColabFold model
FPocket 0.815 · Pocket 3
P2Rank 0.458 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
340 559 Gene3D G3DSA:3.40.50.300 -
340 559 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
86 573 PANTHER PTHR37937 CONJUGATIVE TRANSFER: DNA TRANSPORT
96 564 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
96 564 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
65 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
56 66 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
88 611 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
382 480 CDD cd01127 TrwB_TraG_TraD_VirD4
11 33 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
34 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
67 87 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
39 55 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 572 Pfam PF02534 Type IV secretory system Conjugative DNA transfer
102 572 InterPro IPR003688 Type IV secretion system protein TraG/VirD4
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8F4
AlphaFold — — full sequence — Viewing
ColabFold KP13_06739
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.692
3 0.576

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.08 0.43
2 5.05 0.23
3 2.13 0.049
4 0.81 0.003