Protein profile

KP13_06839

integrase

Genome: KpKP13

Gene: AHE41862.1 Structure source: AlphaFold + ColabFold UniProt A0A1C8Y8G9
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Amino acids 108
Annotations 3
Features 8
PDB binders 0
Druggability 0.419

Overview

Basic information about this protein and its source genome.

Accession
KP13_06839
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41862.1
Status
annotated
Amino acids
108
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
48.81
DEG E-value
2.41e-16
Localization
Cytoplasmic
ColabFold pLDDT
87.07

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.419
Structure A0A1C8Y8G9
Pocket Pocket 1
P2Rank 0.085
Structure A0A1C8Y8G9
Pocket Pocket 1
ColabFold model
FPocket 0.645 · Pocket 4
P2Rank 0.038 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 46 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 97 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
1 97 InterPro IPR002104 Integrase, catalytic domain
1 91 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
1 91 InterPro IPR013762 Integrase-like, catalytic domain superfamily
10 99 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
10 99 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
12 88 Pfam PF00589 Phage integrase family
12 88 InterPro IPR002104 Integrase, catalytic domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1C8Y8G9
AlphaFold — — full sequence — Viewing
ColabFold KP13_06839
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.419