Protein profile

KP13_06840

integrase

Genome: KpKP13

Gene: AHE41863.1 Structure source: AlphaFold + ColabFold UniProt D7R7S3
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Amino acids 165
Annotations 3
Features 14
PDB binders 0
Druggability 0.381

Overview

Basic information about this protein and its source genome.

Accession
KP13_06840
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41863.1
Status
annotated
Amino acids
165
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
92.54

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.381
Structure D7R7S3
Pocket Pocket 4
P2Rank 0.031
Structure D7R7S3
Pocket Pocket 1
ColabFold model
FPocket 0.575 · Pocket 1
P2Rank 0.026 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 81 Gene3D G3DSA:1.10.150.130 -
1 81 InterPro IPR010998 Integrase/recombinase, N-terminal
88 165 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
88 165 InterPro IPR002104 Integrase, catalytic domain
1 76 Pfam PF13495 Phage integrase, N-terminal SAM-like domain
1 76 InterPro IPR004107 Integrase, SAM-like, N-terminal
83 165 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
83 165 InterPro IPR013762 Integrase-like, catalytic domain superfamily
1 71 ProSiteProfiles PS51900 Core-binding (CB) domain profile.
1 71 InterPro IPR044068 Core-binding (CB) domain
92 165 Pfam PF00589 Phage integrase family
92 165 InterPro IPR002104 Integrase, catalytic domain
3 164 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
3 164 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_D7R7S3
AlphaFold — — full sequence — Viewing
ColabFold KP13_06840
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.381

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.23 0.011