Protein profile

KP13_32083

putative exonuclease

Genome: KpKP13

Gene: AHE41868.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H6C6
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Amino acids 289
Annotations 3
Features 10
PDB binders 0
Druggability 0.331

Overview

Basic information about this protein and its source genome.

Accession
KP13_32083
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41868.1
Status
annotated
Amino acids
289
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
94.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331
Structure A0A0H3H6C6
Pocket Pocket 3
P2Rank 0.753
Structure A0A0H3H6C6
Pocket Pocket 1
ColabFold model
FPocket 0.244 · Pocket 2
P2Rank 0.726 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003676 Binding to a nucleic acid.
  • GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
  • GO:0006259 Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
107 253 CDD cd06127 DEDDh
70 286 PANTHER PTHR30231 DNA POLYMERASE III SUBUNIT EPSILON
96 275 SUPERFAMILY SSF53098 Ribonuclease H-like
96 275 InterPro IPR012337 Ribonuclease H-like superfamily
105 274 SMART SM00479 exoiiiendus
105 274 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
107 264 Pfam PF00929 Exonuclease
107 264 InterPro IPR013520 Exonuclease, RNase T/DNA polymerase III
105 279 Gene3D G3DSA:3.30.420.10 -
105 279 InterPro IPR036397 Ribonuclease H superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H6C6
AlphaFold — — full sequence — Viewing
ColabFold KP13_32083
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.331

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 13.0 0.671