Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_05640
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: gin AHE41874.1
Status: annotated
Amino acids: 191
Structure source: ColabFold

GO

GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): N
DEG identity (%): 0.0
Localization: Unknown
ColabFold pLDDT: 84.88

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.782

Structure CB_KP13_05640

Pocket Pocket 12

P2Rank

Structure CB_KP13_05640

Pocket No pockets

ColabFold model

FPocket 0.782 · Pocket 12

Core conservation Accessory gene

Roary accessory

CoreCruncher accessory

Gut microbiome 4 / 4744 genomes with a hit

Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3

GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
144	187	Pfam	PF02796	Helix-turn-helix domain of resolvase
144	187	InterPro	IPR006120	Resolvase, HTH domain
4	140	ProSiteProfiles	PS51736	Resolvase/invertase-type recombinase catalytic domain profile.
4	140	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
6	147	PANTHER	PTHR30461	DNA-INVERTASE FROM LAMBDOID PROPHAGE
6	141	Pfam	PF00239	Resolvase, N terminal domain
6	141	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
5	132	CDD	cd03768	SR_ResInv
5	141	SUPERFAMILY	SSF53041	Resolvase-like
5	141	InterPro	IPR036162	Resolvase-like, N-terminal catalytic domain superfamily
144	191	Gene3D	G3DSA:1.10.10.60	-
144	186	CDD	cd00569	HTH_Hin_like
5	143	Gene3D	G3DSA:3.40.50.1390	-
5	143	InterPro	IPR036162	Resolvase-like, N-terminal catalytic domain superfamily
5	142	SMART	SM00857	resolvase_6
5	142	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
61	73	ProSitePatterns	PS00398	Site-specific recombinases signature 2.
61	73	InterPro	IPR006118	Recombinase, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold KP13_05640	ColabFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
12				0.782
9				0.244