Protein profile

KP13_32087

conjugal transfer TraD-like protein

Genome: KpKP13

Gene: AHE41882.1 Structure source: AlphaFold + ColabFold UniProt A0A7S8H6Q5
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Amino acids 621
Annotations 0
Features 20
PDB binders 0
Druggability 0.623

Overview

Basic information about this protein and its source genome.

Accession
KP13_32087
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41882.1
Status
annotated
Amino acids
621
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
88.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.623
Structure A0A7S8H6Q5
Pocket Pocket 15
P2Rank 0.363
Structure A0A7S8H6Q5
Pocket Pocket 1
ColabFold model
FPocket 0.344 · Pocket 2
P2Rank 0.424 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records
Show feature table
Start End DB Term Name
432 536 CDD cd01127 TrwB_TraG_TraD_VirD4
36 621 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
471 598 Pfam PF12696 TraM recognition site of TraD and TraG
471 598 InterPro IPR032689 TraD/TraG, TraM recognition site
170 297 Pfam PF10412 Type IV secretion-system coupling protein DNA-binding domain
170 297 InterPro IPR019476 Type IV secretion system coupling protein TraD, DNA-binding domain
1 35 Phobius SIGNAL_PEPTIDE Signal peptide region
146 611 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
146 611 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
170 336 PANTHER PTHR37937 CONJUGATIVE TRANSFER: DNA TRANSPORT
1 21 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
22 30 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
409 620 Gene3D G3DSA:3.40.50.300 -
409 620 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
126 241 Gene3D G3DSA:3.40.50.300 -
126 241 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
31 35 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
174 211 CDD cd01127 TrwB_TraG_TraD_VirD4
10 619 NCBIfam TIGR03743 conjugative transfer system coupling protein TraD
10 619 InterPro IPR022458 Conjugative coupling factor TraG/TraD

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A7S8H6Q5
AlphaFold — — full sequence — Viewing
ColabFold KP13_32087
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
15 0.623

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.63 0.201
2 3.73 0.142
3 2.74 0.083
4 1.98 0.042
5 1.4 0.017