Protein profile

KP13_05624

transcriptional repressor protein KorB

Genome: KpKP13

Gene: AHE41903.1 korB Structure source: AlphaFold + ColabFold UniProt A0A0H3GZZ3
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Amino acids 393
Annotations 3
Features 18
PDB binders 0
Druggability 0.383

Overview

Basic information about this protein and its source genome.

Accession
KP13_05624
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41903.1 korB
Status
annotated
Amino acids
393
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
72.17

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.383
Structure A0A0H3GZZ3
Pocket Pocket 20
P2Rank 0.119
Structure A0A0H3GZZ3
Pocket Pocket 1
ColabFold model
FPocket 0.418 · Pocket 17
P2Rank 0.027 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0005694 A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
  • GO:0007059 The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
105 236 Gene3D G3DSA:1.10.10.2830 -
37 98 Gene3D G3DSA:3.90.1530.30 -
218 232 MobiDBLite mobidb-lite consensus disorder prediction
218 327 MobiDBLite mobidb-lite consensus disorder prediction
10 238 PANTHER PTHR33375 CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED
27 102 Pfam PF02195 ParB/Sulfiredoxin domain
27 102 InterPro IPR003115 ParB/Sulfiredoxin
25 115 SMART SM00470 ParB_7
25 115 InterPro IPR003115 ParB/Sulfiredoxin
237 267 MobiDBLite mobidb-lite consensus disorder prediction
293 327 MobiDBLite mobidb-lite consensus disorder prediction
35 193 NCBIfam TIGR00180 ParB/RepB/Spo0J family partition protein
35 193 InterPro IPR004437 ParB/RepB/Spo0J partition protein
111 217 SUPERFAMILY SSF109709 KorB DNA-binding domain-like
134 221 Pfam PF08535 KorB domain
134 221 InterPro IPR013741 Repressor KorB domain
26 154 SUPERFAMILY SSF110849 ParB/Sulfiredoxin
26 154 InterPro IPR036086 ParB/Sulfiredoxin superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZZ3
AlphaFold — — full sequence — Viewing
ColabFold KP13_05624
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.383

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.15 0.05