Protein profile

KP13_06666

putative transposase for insertion sequence element IS408

Genome: KpKP13

Gene: AHE41938.1 Structure source: AlphaFold + ColabFold UniProt A0AB73VYC9
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Amino acids 520
Annotations 2
Features 10
PDB binders 0
Druggability 0.796

Overview

Basic information about this protein and its source genome.

Accession
KP13_06666
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41938.1
Status
annotated
Amino acids
520
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.796
Structure A0AB73VYC9
Pocket Pocket 1
P2Rank 0.083
Structure A0AB73VYC9
Pocket Pocket 1
ColabFold model
FPocket 0.26 · Pocket 4
P2Rank 0.032 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
145 258 Pfam PF00665 Integrase core domain
145 258 InterPro IPR001584 Integrase, catalytic core
11 93 ProSiteProfiles PS50532 IS408 transposase-type HTH domain profile.
11 93 InterPro IPR017895 Helix-turn-helix, IS408/IS1162 transposase-type
133 335 ProSiteProfiles PS50994 Integrase catalytic domain profile.
133 335 InterPro IPR001584 Integrase, catalytic core
138 324 Gene3D G3DSA:3.30.420.10 -
138 324 InterPro IPR036397 Ribonuclease H superfamily
15 330 NCBIfam NF033546 IS21 family transposase
1 419 PANTHER PTHR35004 TRANSPOSASE RV3428C-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0AB73VYC9
AlphaFold — — full sequence — Viewing
ColabFold KP13_06666
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.796
13 0.217

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.27 0.057