Protein profile

KP13_06685

DSBA-like thioredoxin domain-containing protein

Genome: KpKP13

Gene: AHE41945.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZS8
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Amino acids 286
Annotations 2
Features 13
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
KP13_06685
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41945.1
Status
annotated
Amino acids
286
Structure source
AlphaFold + ColabFold
GO
GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
86.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure A0A0H3GZS8
Pocket Pocket 3
P2Rank 0.289
Structure A0A0H3GZS8
Pocket Pocket 1
ColabFold model
FPocket 0.87 · Pocket 1
P2Rank 0.136 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
9 31 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
100 272 SUPERFAMILY SSF52833 Thioredoxin-like
100 272 InterPro IPR036249 Thioredoxin-like superfamily
103 276 PANTHER PTHR13887 GLUTATHIONE S-TRANSFERASE KAPPA
115 251 CDD cd02972 DsbA_family
33 286 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
83 276 ProSiteProfiles PS51352 Thioredoxin domain profile.
83 276 InterPro IPR013766 Thioredoxin domain
97 278 Gene3D G3DSA:3.40.30.10 Glutaredoxin
101 251 Pfam PF13462 Thioredoxin
101 251 InterPro IPR012336 Thioredoxin-like fold
12 32 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZS8
AlphaFold — — full sequence — Viewing
ColabFold KP13_06685
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.827
2 0.403

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.88 0.288
2 3.53 0.13
3 1.97 0.041
4 1.54 0.023
5 1.45 0.019