Protein profile

KP13_06660

Histone-like nucleoid-structuring protein H-NS

Genome: KpKP13

Gene: AHE41962.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H051
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Amino acids 139
Annotations 4
Features 5
PDB binders 0
Druggability 0.567

Overview

Basic information about this protein and its source genome.

Accession
KP13_06660
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41962.1
Status
annotated
Amino acids
139
Structure source
AlphaFold + ColabFold
GO
GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.56

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.567
Structure A0A0H3H051
Pocket Pocket 9
P2Rank
Structure A0A0H3H051
Pocket No pockets
ColabFold model
FPocket 0.767 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

5 records
Show feature table
Start End DB Term Name
17 96 Gene3D G3DSA:1.10.287.1050 -
17 96 InterPro IPR027454 Histone-like protein H-NS, N-terminal
38 76 Coils Coil Coil
52 123 Pfam PF00816 H-NS histone family
52 123 InterPro IPR001801 Histone-like protein H-NS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H051
AlphaFold — — full sequence — Viewing
ColabFold KP13_06660
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.566
2 0.32
6 0.065
1 0.0