Protein profile

KP13_06771

ATP-dependent DNA helicase

Genome: KpKP13

Gene: AHE41970.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GZR2
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Amino acids 503
Annotations 9
Features 13
PDB binders 0
Druggability 0.526

Overview

Basic information about this protein and its source genome.

Accession
KP13_06771
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41970.1
Status
annotated
Amino acids
503
Structure source
AlphaFold + ColabFold
EC
5.6.2.4
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0043138 Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.034
Human E-value
1.19e-66
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.66

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.526
Structure A0A0H3GZR2
Pocket Pocket 7
P2Rank 0.752
Structure A0A0H3GZR2
Pocket Pocket 1
ColabFold model
FPocket 0.451 · Pocket 35
P2Rank 0.64 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 8 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

8
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003678 Unwinding of a DNA helix, driven by ATP hydrolysis.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0043138 Unwinding a DNA helix in the direction 5' to 3', driven by ATP hydrolysis.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0000724 The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
  • GO:0031297 The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
6 250 Gene3D G3DSA:3.40.50.300 -
6 250 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
374 467 Pfam PF13361 UvrD-like helicase C-terminal domain
374 467 InterPro IPR014017 UvrD-like DNA helicase, C-terminal
320 500 Gene3D G3DSA:3.40.50.300 -
320 500 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
389 484 PANTHER PTHR11070 UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER
389 484 InterPro IPR000212 DNA helicase, UvrD/REP type
16 234 Pfam PF13245 AAA domain
5 260 ProSiteProfiles PS51198 UvrD-like DNA helicase ATP-binding domain profile.
5 260 InterPro IPR014016 UvrD-like helicase, ATP-binding domain
8 472 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
8 472 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZR2
AlphaFold — — full sequence — Viewing
ColabFold KP13_06771
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.526
26 0.396
1 0.343

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 9.81 0.527
2 7.19 0.374
3 3.4 0.122