Protein profile

KP13_05667

KfrA protein

Genome: KpKP13

Gene: AHE41971.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H039
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Amino acids 346
Annotations 3
Features 13
PDB binders 0
Druggability 0.341

Overview

Basic information about this protein and its source genome.

Accession
KP13_05667
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41971.1
Status
annotated
Amino acids
346
Structure source
AlphaFold + ColabFold
GO
GO:0008134 Binding to a transcription factor, a protein required to initiate or regulate transcription. GO:0070840 Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. GO:0042803 Binding to an identical protein to form a homodimer.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.825
Human E-value
5.36e-07
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
83.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.341
Structure A0A0H3H039
Pocket Pocket 12
P2Rank
Structure A0A0H3H039
Pocket No pockets
ColabFold model
FPocket 0.673 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0008134 Binding to a transcription factor, a protein required to initiate or regulate transcription.
  • GO:0070840 Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
  • GO:0042803 Binding to an identical protein to form a homodimer.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
84 297 Coils Coil Coil
190 277 MobiDBLite mobidb-lite consensus disorder prediction
305 332 Coils Coil Coil
211 236 MobiDBLite mobidb-lite consensus disorder prediction
327 346 MobiDBLite mobidb-lite consensus disorder prediction
9 129 Pfam PF11740 Plasmid replication region DNA-binding N-term
9 129 InterPro IPR021104 KfrA, N-terminal DNA-binding domain
236 346 Gene3D G3DSA:1.20.5.170 -
261 277 MobiDBLite mobidb-lite consensus disorder prediction
237 259 MobiDBLite mobidb-lite consensus disorder prediction
220 336 Pfam PF10473 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
220 336 InterPro IPR019513 Centromere protein Cenp-F, leucine-rich repeat-containing domain
91 335 SUPERFAMILY SSF57997 Tropomyosin

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H039
AlphaFold — — full sequence — Viewing
ColabFold KP13_05667
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.341
9 0.295