Protein profile

KP13_06654

DNA replication terminus site-binding protein

Genome: KpKP13

Gene: AHE41972.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H029
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Amino acids 291
Annotations 3
Features 6
PDB binders 0
Druggability 0.263

Overview

Basic information about this protein and its source genome.

Accession
KP13_06654
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41972.1
Status
annotated
Amino acids
291
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006274 The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.263
Structure A0A0H3H029
Pocket Pocket 20
P2Rank 0.052
Structure A0A0H3H029
Pocket Pocket 1
ColabFold model
FPocket 0.334 · Pocket 6
P2Rank 0.024 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 2 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006274 The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
4 194 Gene3D G3DSA:3.50.14.10 Replication terminator Tus, domain 1 superfamily/Replication terminator Tus
4 194 InterPro IPR036381 Replication terminator Tus, domain 1
7 286 SUPERFAMILY SSF56596 Replication terminator protein (Tus)
7 286 InterPro IPR036384 Replication terminator Tus superfamily
6 275 Pfam PF05472 DNA replication terminus site-binding protein (Ter protein)
6 275 InterPro IPR008865 DNA replication terminus site-binding protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H029
AlphaFold — — full sequence — Viewing
ColabFold KP13_06654
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
20 0.263
3 0.258
2 0.249