Protein profile

KP13_03985

F-type conjugal transfer protein TraF (F-T4SS)

Genome: KpKP13

Gene: AHE47177.1 Structure source: AlphaFold + ColabFold UniProt A0A024HVU6
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Amino acids 345
Annotations 0
Features 16
PDB binders 0
Druggability 0.657

Overview

Basic information about this protein and its source genome.

Accession
KP13_03985
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47177.1
Status
annotated
Amino acids
345
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
81.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.657
Structure A0A024HVU6
Pocket Pocket 4
P2Rank 0.181
Structure A0A024HVU6
Pocket Pocket 1
ColabFold model
FPocket 0.576 · Pocket 8
P2Rank 0.17 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 5 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 27 SignalP_EUK SignalP-noTM SignalP-noTM
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 25 Phobius SIGNAL_PEPTIDE Signal peptide region
15 275 NCBIfam TIGR02740 TraF-like protein
15 275 InterPro IPR014111 Type IV conjugative transfer system protein TraF-like
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 10 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
44 265 Pfam PF13728 F plasmid transfer operon protein
44 265 InterPro IPR039555 F plasmid transfer operon protein
138 269 Gene3D G3DSA:3.40.30.10 Glutaredoxin
26 345 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
52 77 MobiDBLite mobidb-lite consensus disorder prediction
162 265 SUPERFAMILY SSF52833 Thioredoxin-like
162 265 InterPro IPR036249 Thioredoxin-like superfamily
20 25 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
11 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A024HVU6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03985
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.657
16 0.224