Protein profile

KP13_03732

Signal peptidase S49

Genome: KpKP13

Gene: AHE47187.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QZL6
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Amino acids 378
Annotations 4
Features 16
PDB binders 0
Druggability 0.313

Overview

Basic information about this protein and its source genome.

Accession
KP13_03732
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47187.1
Status
annotated
Amino acids
378
Structure source
AlphaFold + ColabFold
EC
3.4.21.-
GO
GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
No hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
84.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.313
Structure A0A1J0QZL6
Pocket Pocket 23
P2Rank 0.119
Structure A0A1J0QZL6
Pocket Pocket 1
ColabFold model
FPocket 0.053 · Pocket 1
P2Rank 0.115 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 0 / 4744 genomes with a hit
Normalized 0

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 3 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

3
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0008236 Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
67 332 CDD cd07023 S49_Sppa_N_C
67 332 InterPro IPR047272 Signal peptide peptidase A-like, C-terminal
226 288 Gene3D G3DSA:6.20.330.10 -
186 323 SUPERFAMILY SSF52096 ClpP/crotonase
186 323 InterPro IPR029045 ClpP/crotonase-like domain superfamily
33 55 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
183 332 Pfam PF01343 Peptidase family S49
183 332 InterPro IPR002142 Peptidase S49
61 335 Gene3D G3DSA:3.90.226.10 -
33 55 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 32 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
137 161 MobiDBLite mobidb-lite consensus disorder prediction
59 130 SUPERFAMILY SSF52096 ClpP/crotonase
59 130 InterPro IPR029045 ClpP/crotonase-like domain superfamily
56 378 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
54 132 PANTHER PTHR42987 PEPTIDASE S49

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QZL6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03732
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
23 0.313

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.45 0.067