Protein profile

KP13_01444

transposase for insertion sequence element IS1328

Genome: KpKP13

Gene: AHE47225.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H166
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Amino acids 334
Annotations 3
Features 9
PDB binders 0
Druggability 0.783

Overview

Basic information about this protein and its source genome.

Accession
KP13_01444
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47225.1
Status
annotated
Amino acids
334
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.85

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.783
Structure A0A0H3H166
Pocket Pocket 26
P2Rank 0.191
Structure A0A0H3H166
Pocket Pocket 1
ColabFold model
FPocket 0.353 · Pocket 18
P2Rank 0.192 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
185 205 Coils Coil Coil
210 285 Pfam PF02371 Transposase IS116/IS110/IS902 family
210 285 InterPro IPR003346 Transposase IS116/IS110/IS902, C-terminal
7 330 NCBIfam NF033542 IS110 family transposase
7 330 InterPro IPR047650 Transposase IS110-like
7 147 Pfam PF01548 Transposase
7 147 InterPro IPR002525 Transposase IS110-like, N-terminal
5 333 PANTHER PTHR33055 TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS1111A
5 333 InterPro IPR047650 Transposase IS110-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H166
AlphaFold — — full sequence — Viewing
ColabFold KP13_01444
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
26 0.783

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.24 0.055
2 1.85 0.036