Protein profile
KP13_31585
Mercuric transport protein periplasmic component
Genome: KpKP13
Overview
Basic information about this protein and its source genome.
- Accession
- KP13_31585
- Gene
- merP AHE47228.1
- Status
- annotated
- Amino acids
- 91
- Structure source
- AlphaFold + ColabFold
Target profile
Computed evidence for target prioritization.
- Human off-target
- hit
- Human identity (%)
- 32.836
- Human E-value
- 2.39e-07
- Gut microbiome off-target
- hit
- Essential (DEG)
- N
- DEG identity (%)
- 0.0
- Localization
- Unknown
- ColabFold pLDDT
- 84.63
Selected Druggability evidence
AlphaFold / UniProt modelSelected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
Gene Ontology (GO)
6- GO:0045340 Binding to a mercury ion (Hg2+).
- GO:0015097 Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other.
- GO:0015694 The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
- GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
- GO:0046872 Binding to a metal ion.
- GO:0046689 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
Sequence Features
Domain/signature hits from InterPro and related databases.
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 25 | 88 | CDD | cd00371 | HMA |
| 25 | 88 | InterPro | IPR006121 | Heavy metal-associated domain, HMA |
| 20 | 91 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 20 | 91 | Gene3D | G3DSA:3.30.70.100 | - |
| 1 | 19 | SignalP_EUK | SignalP-noTM | SignalP-noTM |
| 28 | 57 | ProSitePatterns | PS01047 | Heavy-metal-associated domain. |
| 28 | 57 | InterPro | IPR017969 | Heavy-metal-associated, conserved site |
| 4 | 14 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 1 | 3 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 1 | 19 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 17 | 89 | SUPERFAMILY | SSF55008 | HMA, heavy metal-associated domain |
| 17 | 89 | InterPro | IPR036163 | Heavy metal-associated domain superfamily |
| 1 | 91 | NCBIfam | TIGR02052 | mercury resistance system periplasmic binding protein MerP |
| 1 | 91 | InterPro | IPR011795 | Mercuric transport protein periplasmic component |
| 20 | 88 | PANTHER | PTHR46594 | P-TYPE CATION-TRANSPORTING ATPASE |
| 22 | 88 | ProSiteProfiles | PS50846 | Heavy-metal-associated domain profile. |
| 22 | 88 | InterPro | IPR006121 | Heavy metal-associated domain, HMA |
| 1 | 19 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 2 | 20 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 2 | 20 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 20 | 31 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 20 | 31 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 62 | 76 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 62 | 76 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 31 | 47 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 31 | 47 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 47 | 62 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 47 | 62 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 76 | 90 | PRINTS | PR00946 | Mercury scavenger protein signature |
| 76 | 90 | InterPro | IPR001802 | Mercuric transport protein periplasmic component/copper chaperone CopZ |
| 15 | 19 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 20 | 90 | FunFam | G3DSA:3.30.70.100:FF:000005 | Copper-exporting P-type ATPase A |
| 25 | 85 | Pfam | PF00403 | Heavy-metal-associated domain |
| 25 | 85 | InterPro | IPR006121 | Heavy metal-associated domain, HMA |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
Loading 3D structure...
Structural evidence
0 + 2Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.
| Entry | Method | Resolution | Chain | Coverage | Links | Status |
|---|---|---|---|---|---|---|
|
AlphaFold
AF_A0A0H3H5J8
|
AlphaFold | — | — | full sequence | — | Viewing |
|
ColabFold
KP13_31585
|
ColabFold | — | — | full sequence | — | Loaded |
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.28 |
Pockets (FPOCKET)
Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).
| FPOCKET | Sticks | Spheres | Surfaces | Druggability | Labels | Zoom | Positions |
|---|---|---|---|---|---|---|---|
| 1 | 0.465 |
Ligand evidence
Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.
Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.
No PDB structure with a co-crystallized ligand found for this exact protein.
Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.
| Ligand | Source crystal | UniProt (homolog) | MW · LogP · TPSA | Lipinski | PAINS | SMILES |
|---|---|---|---|---|---|---|
| 9UX | P35670 | 292.0 Da LogP -0.02 TPSA 34.1 | ✓ Ro5 | ✓ Clean |
O=[MoH2]1S[MoH2](=O)S1
|
Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL bioactivity data found for this exact protein.
Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).
No ChEMBL hits found through similar proteins.
Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).
No virtual-screening candidates for this protein.
PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.