Protein profile

KP13_31579

HTH-type transcriptional regulator merD

Genome: KpKP13

Gene: AHE47231.1 merD Structure source: AlphaFold + ColabFold UniProt A0A0H3GYQ6
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Amino acids 120
Annotations 5
Features 19
PDB binders 0
Druggability 0.548

Overview

Basic information about this protein and its source genome.

Accession
KP13_31579
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47231.1 merD
Status
annotated
Amino acids
120
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0046689 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.548
Structure A0A0H3GYQ6
Pocket Pocket 1
P2Rank
Structure A0A0H3GYQ6
Pocket No pockets
ColabFold model
FPocket 0.546 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 22 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0046689 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
1 118 Gene3D G3DSA:1.10.1660.10 -
3 106 PANTHER PTHR30204 REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR
3 106 InterPro IPR047057 MerR transcriptional regulator
4 109 SUPERFAMILY SSF46955 Putative DNA-binding domain
4 109 InterPro IPR009061 Putative DNA-binding domain superfamily
1 115 NCBIfam TIGR02054 mercuric resistance transcriptional repressor protein MerD
1 115 InterPro IPR011797 Mercuric resistence transcriptional repressor protein MerD
3 72 ProSiteProfiles PS50937 MerR-type HTH domain profile.
3 72 InterPro IPR000551 MerR-type HTH domain
4 73 SMART SM00422 merrmega3
4 73 InterPro IPR000551 MerR-type HTH domain
40 60 PRINTS PR00040 MerR bacterial regulatory protein HTH signature
40 60 InterPro IPR000551 MerR-type HTH domain
16 29 PRINTS PR00040 MerR bacterial regulatory protein HTH signature
16 29 InterPro IPR000551 MerR-type HTH domain
5 16 PRINTS PR00040 MerR bacterial regulatory protein HTH signature
5 16 InterPro IPR000551 MerR-type HTH domain
4 72 Pfam PF13411 MerR HTH family regulatory protein
4 72 InterPro IPR000551 MerR-type HTH domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYQ6
AlphaFold — — full sequence — Viewing
ColabFold KP13_31579
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.548
7 0.377
9 0.281
8 0.226