Protein profile

KP13_01437

putative mercuric resistance protein

Genome: KpKP13

Gene: merE AHE47232.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H5K3
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Amino acids 78
Annotations 3
Features 9
PDB binders 0
Druggability 0.861

Overview

Basic information about this protein and its source genome.

Accession
KP13_01437
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
merE AHE47232.1
Status
annotated
Amino acids
78
Structure source
AlphaFold + ColabFold
GO
GO:0015097 Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other. GO:0015694 The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
58.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.861
Structure A0A0H3H5K3
Pocket Pocket 1
P2Rank
Structure A0A0H3H5K3
Pocket No pockets
ColabFold model
FPocket 0.832 · Pocket 10
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0015097 Enables the transfer of mercury (Hg2+) ions from one side of a membrane to the other.
  • GO:0015694 The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
18 40 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
72 78 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
52 71 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
52 71 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 42 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 74 Pfam PF05052 MerE protein
1 74 InterPro IPR007746 Broad mercury transporter MerE
41 51 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 17 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H5K3
AlphaFold — — full sequence — Viewing
ColabFold KP13_01437
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.861