Protein profile

KP13_01435

Integrase core subunit

Genome: KpKP13

Gene: AHE47234.1 rve Structure source: AlphaFold + ColabFold UniProt A0A0H3H178
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Amino acids 434
Annotations 2
Features 9
PDB binders 0
Druggability 0.57

Overview

Basic information about this protein and its source genome.

Accession
KP13_01435
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47234.1 rve
Status
annotated
Amino acids
434
Structure source
AlphaFold + ColabFold
GO
GO:0003676 Binding to a nucleic acid. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
80.44

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.57
Structure A0A0H3H178
Pocket Pocket 5
P2Rank 0.315
Structure A0A0H3H178
Pocket Pocket 1
ColabFold model
FPocket 0.597 · Pocket 5
P2Rank 0.244 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 11 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003676 Binding to a nucleic acid.
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
38 96 Pfam PF13518 Helix-turn-helix domain
182 380 SUPERFAMILY SSF53098 Ribonuclease H-like
182 380 InterPro IPR012337 Ribonuclease H-like superfamily
183 401 Gene3D G3DSA:3.30.420.10 -
183 401 InterPro IPR036397 Ribonuclease H superfamily
184 387 ProSiteProfiles PS50994 Integrase catalytic domain profile.
184 387 InterPro IPR001584 Integrase, catalytic core
186 308 Pfam PF00665 Integrase core domain
186 308 InterPro IPR001584 Integrase, catalytic core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H178
AlphaFold — — full sequence — Viewing
ColabFold KP13_01435
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.085
1 0.028
7 0.002
19 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 7.22 0.315
2 4.21 0.141