Protein profile

KP13_03961

ATP-binding protein

Genome: KpKP13

Gene: AHE47238.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QZG4
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Amino acids 335
Annotations 3
Features 11
PDB binders 0
Druggability 0.169

Overview

Basic information about this protein and its source genome.

Accession
KP13_03961
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47238.1
Status
annotated
Amino acids
335
Structure source
AlphaFold + ColabFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.179
Human E-value
2.19e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.91

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.169
Structure A0A1J0QZG4
Pocket Pocket 17
P2Rank 0.402
Structure A0A1J0QZG4
Pocket Pocket 1
ColabFold model
FPocket 0.175 · Pocket 6
P2Rank 0.293 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 4 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
76 214 PANTHER PTHR21610 VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8
76 214 InterPro IPR039891 von Willebrand factor A domain-containing protein 8
89 228 Pfam PF07728 AAA domain (dynein-related subfamily)
89 228 InterPro IPR011704 ATPase, dynein-related, AAA domain
76 292 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
76 292 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
73 213 CDD cd00009 AAA
72 242 Gene3D G3DSA:3.40.50.300 -
72 242 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
85 237 SMART SM00382 AAA_5
85 237 InterPro IPR003593 AAA+ ATPase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QZG4
AlphaFold — — full sequence — Viewing
ColabFold KP13_03961
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.9 0.092
2 1.72 0.03
3 1.69 0.029
4 1.65 0.027