Protein profile

KP13_03968

Toxin relE

Genome: KpKP13

Gene: AHE47244.1 Structure source: AlphaFold + ColabFold UniProt A0A3R9ZL81
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Amino acids 94
Annotations 0
Features 9
PDB binders 0
Druggability 0.492

Overview

Basic information about this protein and its source genome.

Accession
KP13_03968
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47244.1
Status
annotated
Amino acids
94
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
60.227
DEG E-value
3.96e-33
Localization
Cytoplasmic
ColabFold pLDDT
93.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.492
Structure A0A3R9ZL81
Pocket Pocket 6
P2Rank
Structure A0A3R9ZL81
Pocket No pockets
ColabFold model
FPocket 0.08 · Pocket 4
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
6 84 Pfam PF05016 ParE toxin of type II toxin-antitoxin system, parDE
6 84 InterPro IPR007712 Toxin-antitoxin system, RelE/ParE toxin family
4 82 NCBIfam TIGR02385 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family
4 82 InterPro IPR007712 Toxin-antitoxin system, RelE/ParE toxin family
1 83 SUPERFAMILY SSF143011 RelE-like
1 83 InterPro IPR035093 Toxin-antitoxin system, RelE/ParE toxin domain superfamily
1 93 Gene3D G3DSA:3.30.2310.20 -
1 93 InterPro IPR035093 Toxin-antitoxin system, RelE/ParE toxin domain superfamily
1 88 PANTHER PTHR35601 TOXIN RELE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A3R9ZL81
AlphaFold — — full sequence — Viewing
ColabFold KP13_03968
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.492