Protein profile

KP13_03969

putative transposase

Genome: KpKP13

Gene: AHE47245.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QZG6
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Amino acids 426
Annotations 4
Features 11
PDB binders 0
Druggability 0.12

Overview

Basic information about this protein and its source genome.

Accession
KP13_03969
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47245.1
Status
annotated
Amino acids
426
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0046872 Binding to a metal ion. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0032196 Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
89.2

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.12
Structure A0A1J0QZG6
Pocket Pocket 12
P2Rank 0.33
Structure A0A1J0QZG6
Pocket Pocket 1
ColabFold model
FPocket 0.68 · Pocket 8
P2Rank 0.364 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0046872 Binding to a metal ion.
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0032196 Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites. For elements that are transcribed as the first step of transposition, the process starts with the transcription of the transposable element, its translation and maturation, and ending with integration into DNA. For elements that are cut out, the process starts with the excision of the donor DNA and integrated into another site.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
185 298 Pfam PF01385 Probable transposase
185 298 InterPro IPR001959 Probable transposase, IS891/IS1136/IS1341
73 398 PANTHER PTHR36172 -
267 354 NCBIfam TIGR01766 IS200/IS605 family accessory protein TnpB-like domain
267 354 InterPro IPR010095 Cas12f1-like, TNB domain
327 394 Pfam PF07282 Putative transposase DNA-binding domain
327 394 InterPro IPR010095 Cas12f1-like, TNB domain
25 395 NCBIfam NF040570 RNA-guided endonuclease TnpB family protein
19 66 Pfam PF12323 Helix-turn-helix domain
19 66 InterPro IPR021027 Transposase, putative, helix-turn-helix domain
1 17 SignalP_EUK SignalP-noTM SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QZG6
AlphaFold — — full sequence — Viewing
ColabFold KP13_03969
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.45 0.125
2 1.49 0.021