Protein profile

KP13_03970

putative transposase

Genome: KpKP13

Gene: AHE47246.1 Structure source: AlphaFold + ColabFold UniProt A0A1J0QZG1
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Amino acids 133
Annotations 3
Features 10
PDB binders 0
Druggability 0.466

Overview

Basic information about this protein and its source genome.

Accession
KP13_03970
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47246.1
Status
annotated
Amino acids
133
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
93.69

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.466
Structure A0A1J0QZG1
Pocket Pocket 9
P2Rank
Structure A0A1J0QZG1
Pocket No pockets
ColabFold model
FPocket 0.448 · Pocket 9
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 17 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
3 132 PANTHER PTHR33360 TRANSPOSASE FOR INSERTION SEQUENCE ELEMENT IS200
4 131 SUPERFAMILY SSF143422 Transposase IS200-like
4 131 InterPro IPR036515 Transposase IS200-like superfamily
1 132 Gene3D G3DSA:3.30.70.1290 -
1 132 InterPro IPR036515 Transposase IS200-like superfamily
12 131 SMART SM01321 Y1_Tnp_2
12 131 InterPro IPR002686 Transposase IS200-like
7 130 NCBIfam NF033573 IS200/IS605 family transposase
14 131 Pfam PF01797 Transposase IS200 like
14 131 InterPro IPR002686 Transposase IS200-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A1J0QZG1
AlphaFold — — full sequence — Viewing
ColabFold KP13_03970
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
9 0.466