Protein profile

KP13_32057

transposase insH for insertion sequence element IS5

Genome: KpKP13

Gene: AHE47261.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQP9
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Amino acids 326
Annotations 3
Features 7
PDB binders 0
Druggability 0.5

Overview

Basic information about this protein and its source genome.

Accession
KP13_32057
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47261.1
Status
annotated
Amino acids
326
Structure source
AlphaFold + ColabFold
GO
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
98.773
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
92.11

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.5
Structure A0A0H3GQP9
Pocket Pocket 1
P2Rank 0.184
Structure A0A0H3GQP9
Pocket Pocket 1
ColabFold model
FPocket 0.865 · Pocket 2
P2Rank 0.136 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 35 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
  • GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
138 312 Pfam PF01609 Transposase DDE domain
138 312 InterPro IPR002559 Transposase IS4-like domain
51 124 Pfam PF05598 Transposase domain (DUF772)
51 124 InterPro IPR008490 Transposase InsH, N-terminal
24 313 NCBIfam NF033581 IS5 family transposase
1 325 PANTHER PTHR35604 TRANSPOSASE INSH FOR INSERTION SEQUENCE ELEMENT IS5A-RELATED
319 326 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQP9
AlphaFold — — full sequence — Viewing
ColabFold KP13_32057
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.5
3 0.463
2 0.374
10 0.372

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.32 0.117
2 2.54 0.072
3 1.99 0.043
4 1.61 0.026
5 1.51 0.022