Protein profile

KP13_03119

Integrase/recombinase

Genome: KpKP13

Gene: AHE47305.1 int Structure source: AlphaFold + ColabFold UniProt A0A0H3GZJ0
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Amino acids 337
Annotations 3
Features 18
PDB binders 0
Druggability 0.526

Overview

Basic information about this protein and its source genome.

Accession
KP13_03119
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE47305.1 int
Status
annotated
Amino acids
337
Structure source
AlphaFold + ColabFold
GO
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
90.72

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.526
Structure A0A0H3GZJ0
Pocket Pocket 4
P2Rank 0.398
Structure A0A0H3GZJ0
Pocket Pocket 1
ColabFold model
FPocket 0.461 · Pocket 9
P2Rank 0.446 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
112 315 CDD cd01193 INT_IntI_C
112 317 PANTHER PTHR30349 PHAGE INTEGRASE-RELATED
116 317 Pfam PF00589 Phage integrase family
116 317 InterPro IPR002104 Integrase, catalytic domain
13 100 Gene3D G3DSA:1.10.150.130 -
13 100 InterPro IPR010998 Integrase/recombinase, N-terminal
14 94 ProSiteProfiles PS51900 Core-binding (CB) domain profile.
14 94 InterPro IPR044068 Core-binding (CB) domain
17 98 Pfam PF13495 Phage integrase, N-terminal SAM-like domain
17 98 InterPro IPR004107 Integrase, SAM-like, N-terminal
16 316 SUPERFAMILY SSF56349 DNA breaking-rejoining enzymes
16 316 InterPro IPR011010 DNA breaking-rejoining enzyme, catalytic core
106 318 Gene3D G3DSA:1.10.443.10 Intergrase catalytic core
106 318 InterPro IPR013762 Integrase-like, catalytic domain superfamily
112 328 ProSiteProfiles PS51898 Tyrosine recombinase domain profile.
112 328 InterPro IPR002104 Integrase, catalytic domain
16 330 NCBIfam TIGR02249 integron integrase
16 330 InterPro IPR011946 Integrase, integron-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZJ0
AlphaFold — — full sequence — Viewing
ColabFold KP13_03119
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.526
24 0.321
12 0.262

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 4.58 0.197
2 2.12 0.049